Palladium-catalyzed [3C + 2C + 2C] cycloaddition of enynylidenecyclopropanes: efficient construction of fused 5-7-5 tricyclic systems

Palladium-catalyzed [3C + 2C + 2C] cycloaddition of enynylidenecyclopropanes: efficient construction of fused 5-7-5 tricyclic systems

We report a Pd-catalyzed intramolecular [3C + 2C + 2C] cycloaddition between alkylidenecyclopropanes, alkynes and alkenes. The method provides synthetically relevant 5-7-5 tricyclic structures, with good chemoselectivity and complete diastereoselectivity.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2010-01, Vol.46 (2), p.270-272
Hauptverfasser: Bhargava, Gaurav, Trillo, Beatriz, Araya, Marisel, López, Fernando, Castedo, Luis, Mascareñas, José L
Format: Artikel
Sprache:eng
Schlagworte:
Alkenes
Alkynes
Construction
Cycloaddition
Palladium
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Zusammenfassung:We report a Pd-catalyzed intramolecular [3C + 2C + 2C] cycloaddition between alkylidenecyclopropanes, alkynes and alkenes. The method provides synthetically relevant 5-7-5 tricyclic structures, with good chemoselectivity and complete diastereoselectivity.
ISSN:1359-7345
1364-548X
DOI:10.1039/b919258a