Combination of a TLR4 ligand and anaphylatoxin C5a for the induction of antigen-specific cytotoxic T cell responses

Highlights ► Anaphylatoxin C5a and the extra domain A (EDA) from fibronectin induce DC maturation. ► Fusion of C5a and EDA to an antigen improve the immunogenicity of the antigen in vivo. ► EDA–C5a–antigen fusion proteins can be useful as anti-tumor/anti-viral vaccines.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2012-04, Vol.30 (18), p.2848-2858
Hauptverfasser:	Rudilla, Francesc, Fayolle, Catherine, Casares, Noelia, Durantez, Maika, Arribillaga, Laura, Lozano, Teresa, Villanueva, Lorea, Pio, Ruben, Sarobe, Pablo, Leclerc, Claude, Prieto, Jesús, Lasarte, Juan José
Format:	Artikel
Sprache:	eng
Schlagworte:	adaptive immunity Adjuvant Allergy and Immunology Anaphylatoxin C5a Anaphylatoxins Anaphylatoxins - genetics Anaphylatoxins - immunology Animals Antigen-presenting cells Antigens Antiviral agents C5a Cancer Vaccines - administration & dosage Cancer Vaccines - immunology CCL17 protein Cell activation cell movement Chemokines complement Complement C5a - genetics Complement C5a - immunology complement component C5a CXCL12 protein Cytokines Cytokines - secretion Cytotoxicity Dendritic cell Dendritic cells DNA Ectodysplasins - genetics Ectodysplasins - immunology EDA Epitopes Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology Female Fibronectin fibronectins Fusion protein immune response Immune system Immunization Immunogenicity Inflammation Interleukin 10 Leukocyte migration Lymphocytes T Mice Mice, Inbred C57BL Myeloid cells Natural killer cells Neoplasms - immunology Neoplasms - prevention & control Ovalbumin Plasmids recombinant fusion proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - immunology T-lymphocytes T-Lymphocytes, Cytotoxic - immunology TLR4 protein Toll-Like Receptor 4 - agonists Toll-like receptors Tumors Vaccine Vaccines Vaccines, DNA - administration & dosage Vaccines, DNA - immunology
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Beschreibung
Zusammenfassung:	Highlights ► Anaphylatoxin C5a and the extra domain A (EDA) from fibronectin induce DC maturation. ► Fusion of C5a and EDA to an antigen improve the immunogenicity of the antigen in vivo. ► EDA–C5a–antigen fusion proteins can be useful as anti-tumor/anti-viral vaccines.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.02.052