Partial Biodistribution and Pharmacokinetics of Isoniazid and Rifabutin Following Pulmonary Delivery of Inhalable Microparticles to Rhesus Macaques

Dry powder inhalations (DPI) of microparticles containing isoniazid (INH) and rifabutin (RFB) are under preclinical development for use in pulmonary tuberculosis. Microparticles containing 0.25, 2.5, or 25 mg of each drug were administered daily for 90 days to rhesus macaques (n = 4/group). Single i...

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Veröffentlicht in:	Molecular pharmaceutics 2012-04, Vol.9 (4), p.1011-1016
Hauptverfasser:	Verma, Rahul Kumar, Mukker, Jatinder Kaur, Singh, Ravi Shankar Prasad, Kumar, Kaushlendra, Verma, Priya Ranjan Prasad, Misra, Amit
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Isoniazid - pharmacokinetics Lung - metabolism Macaca mulatta Rifabutin - pharmacokinetics
Online-Zugang:	Volltext
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