Validity of the Oxford classification of IgA nephropathy in children

Background In 2009, the Oxford classification of IgA nephropathy was published. However, its validity has not been fully examined in children. This study aimed to assess this system in an independent large-scale cohort of children. Methods We analyzed 161 consecutive children with newly diagnosed Ig...

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Veröffentlicht in:	Pediatric nephrology (Berlin, West) West), 2012-05, Vol.27 (5), p.783-792
Hauptverfasser:	Shima, Yuko, Nakanishi, Koichi, Hama, Taketsugu, Mukaiyama, Hironobu, Togawa, Hiroko, Hashimura, Yuya, Kaito, Hiroshi, Sako, Mayumi, Iijima, Kazumoto, Yoshikawa, Norishige
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age of Onset Anti-Inflammatory Agents - therapeutic use Atrophy Biopsy Child Child, Preschool Children Chronic kidney failure Classification Cohort Studies Creatinine Endpoint Determination Female Fibrosis Follow-Up Studies Glomerular Mesangium - pathology Glomerulonephritis, IGA - classification Glomerulonephritis, IGA - pathology Glomerulosclerosis, Focal Segmental - pathology Humans Immunoglobulin A Immunosuppressive Agents - therapeutic use Kaplan-Meier Estimate Kidney - pathology Kidney diseases Kidney Glomerulus - pathology Kidney Tubules - pathology Male Medical prognosis Medicine Medicine & Public Health Nephrology Original Article Pediatrics Prednisolone - therapeutic use Proteins Proteinuria - etiology Reproducibility of Results Survival Analysis Treatment Outcome Urology Validity Variables Young Adult
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Zusammenfassung:	Background In 2009, the Oxford classification of IgA nephropathy was published. However, its validity has not been fully examined in children. This study aimed to assess this system in an independent large-scale cohort of children. Methods We analyzed 161 consecutive children with newly diagnosed IgA nephropathy from 1977 to 1989 retrospectively. We examined the ability of each variable in the Oxford classification as a predictor of renal outcome defined as ≥ stage III chronic kidney disease (CKD) (estimated glomerular filtration rate (eGFR)
ISSN:	0931-041X 1432-198X
DOI:	10.1007/s00467-011-2061-0