Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides

The direct synthesis of dithiophenol maleimide functional polymers by living radical polymerisation is described without the need for protecting group chemistry. The synthesised polymers have been successfully employed as disulfide bridging agents for salmon calcitonin when used in equimolar quantit...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2012-04, Vol.48 (34), p.4064-4066
Hauptverfasser:	Jones, Mathew W, Strickland, Rachel A, Schumacher, Felix F, Caddick, Stephen, Baker, James R, Gibson, Matthew I, Haddleton, David M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bridging Calcitonin - chemistry Disulfides Disulfides - chemical synthesis Disulfides - chemistry Maleimides - chemical synthesis Maleimides - chemistry Models, Molecular Phenol - chemical synthesis Phenol - chemistry Polymerization Polymers Polymers - chemical synthesis Polymers - chemistry Purification Radicals Salmon Strategy Sulfhydryl Compounds - chemical synthesis Sulfhydryl Compounds - chemistry Synthesis
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Beschreibung
Zusammenfassung:	The direct synthesis of dithiophenol maleimide functional polymers by living radical polymerisation is described without the need for protecting group chemistry. The synthesised polymers have been successfully employed as disulfide bridging agents for salmon calcitonin when used in equimolar quantities, negating the requirement for complex purification strategies, traditionally associated with peptide bioconjugation.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c2cc30259d