Copy number variations in affective disorders and meta-analysis

In two recent studies 10 copy number variants (CNV) were found to be overrepresented either among patients suffering from affective disorders in an Amish family or in the Wellcome Trust Case-Control Consortium study. Here, we investigate if these variants are associated with affective disorders in a...

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Veröffentlicht in:	Psychiatric genetics 2011-12, Vol.21 (6), p.319-322
Hauptverfasser:	Olsen, Line, Hansen, Thomas, Djurovic, Srdjan, Haastrup, Eva, Albrecthsen, Anders, Hoeffding, Louise K E, Secher, Anna, Gustafsson, Omar, Jakobsen, Klaus D, Nielsen, Finn C, Ullum, Henrik, Morken, Gunnar, Agartz, Ingrid, Melle, Ingrid, Gether, Ulrik, Andreassen, Ole A, Werge, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Bipolar Disorder - genetics Case-Control Studies DNA Copy Number Variations - genetics Genetic Predisposition to Disease Humans Mood Disorders - genetics Scandinavian and Nordic Countries
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Zusammenfassung:	In two recent studies 10 copy number variants (CNV) were found to be overrepresented either among patients suffering from affective disorders in an Amish family or in the Wellcome Trust Case-Control Consortium study. Here, we investigate if these variants are associated with affective disorders in a combined analysis of three case-control samples from Denmark, Norway and Iceland. A total of 1897 cases (n=1223 unipolar and n=463 bipolar) and 11 231 controls were analyzed for CNVs at the 10 genomic loci, but we found no combined association between these CNVs and affective disorders.
ISSN:	0955-8829 1473-5873
DOI:	10.1097/YPG.0b013e3283463deb