Control of coronary blood flow during exercise

During exercise, coronary blood flow increases to match the augmented myocardial oxygen demand because of tachycardia. Coronary vasodilation during exercise is via a combination of feedforward and feedback control mechanisms. Feedforward control is mediated by sympathetic β-adrenoceptor vasodilation...

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Veröffentlicht in:	Exercise and sport sciences reviews 2012-01, Vol.40 (1), p.37-42
Hauptverfasser:	Gorman, Mark W, Feigl, Eric O
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Nucleotides - blood Adenine Nucleotides - pharmacology Blood Blood flow Coronary Circulation - physiology Exercise Exercise - physiology Feedback Humans Oxygen Consumption - physiology Receptors, Purinergic - blood Receptors, Purinergic - metabolism Sports Vasodilation - drug effects Vasodilation - physiology
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Beschreibung
Zusammenfassung:	During exercise, coronary blood flow increases to match the augmented myocardial oxygen demand because of tachycardia. Coronary vasodilation during exercise is via a combination of feedforward and feedback control mechanisms. Feedforward control is mediated by sympathetic β-adrenoceptor vasodilation. Feedback vasodilator control is via a novel hypothesis where adenine nucleotides released from red blood cells act on endothelial purinergic receptors.
ISSN:	0091-6331 1538-3008
DOI:	10.1097/JES.0b013e3182348cdd