Interferon-Alpha-2a and Zinc Combination Therapy in Children with Chronic Hepatitis B Infection

Zinc has been reported to enhance the response to interferon (IFN) or PEG-IFN plus ribavirin therapy, improve liver function, and ameliorate hematologic side effects in patients with chronic hepatitis C. However, the role of zinc supplementation during IFN therapy in chronic hepatitis B infection (C...

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Veröffentlicht in:Biological trace element research 2011-12, Vol.143 (3), p.1302-1309
Hauptverfasser: Kuloğlu, Zarife, Kırbaş, Gülnihan, Erden, Esra, Kansu, Aydan
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Sprache:eng
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Zusammenfassung:Zinc has been reported to enhance the response to interferon (IFN) or PEG-IFN plus ribavirin therapy, improve liver function, and ameliorate hematologic side effects in patients with chronic hepatitis C. However, the role of zinc supplementation during IFN therapy in chronic hepatitis B infection (CHB) remains unclear. We therefore aimed to report the results of zinc and IFN-alpha-2a therapy in children with CHB. Twenty-two naive, HBeAg-positive children (mean age 10.4 ± 4.4 years) received IFN-α2a (9 MU/m2 sc) for 6 months plus peroral zinc (7.5 mg/day for 10 years) for 12 months. Serum zinc, alanine aminotransferase (ALT), complete blood count, hepatitis B virus DNA (HBV DNA), and serological markers were measured. Histological (HR) and sustained response (SR) were evaluated at 6 months after completion of therapy. Normalization of ALT, HBeAg seroconversion, and HBV DNA 
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-011-8971-7