Effect of Inhibitors of Inducible and Neuronal NO Synthases on the Development of Audiogenic Stress-Induced Damage in Krushinskii-Molodkina Rats

Experiments on the models of epileptiform seizure and hemorrhagic stroke (Krushinskii-Molodkina rats) showed that selective inhibitors of inducible and neuronal NO synthases (aminoguanidine and 7-nitroindazole) significantly decrease the mortality rate, reduce the severity of motor disorders, and pr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2010-12, Vol.150 (1), p.32-35
Hauptverfasser:	Krushinskii, A. L, Kuzenkov, V. S, D'yakonova, V. E, Reutov, V. P
Format:	Artikel
Sprache:	eng
Schlagworte:	7-nitroindazole aminoguanidine Animals Biomedical and Life Sciences Biomedicine Cell Biology Enzyme Inhibitors - therapeutic use Guanidines - therapeutic use Indazoles - therapeutic use Internal Medicine Laboratory Medicine Male Neurons Nitric oxide nitric oxide cycle Nitric Oxide Synthase Type I - antagonists & inhibitors Nitric Oxide Synthase Type III - antagonists & inhibitors Pathology Physiological aspects Rats Seizures (Medicine) Seizures - drug therapy Seizures - prevention & control Shock, Hemorrhagic - prevention & control sodium nitrite Stress, Physiological - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Experiments on the models of epileptiform seizure and hemorrhagic stroke (Krushinskii-Molodkina rats) showed that selective inhibitors of inducible and neuronal NO synthases (aminoguanidine and 7-nitroindazole) significantly decrease the mortality rate, reduce the severity of motor disorders, and prevent the development of intracranial hemorrhages under conditions of audiogenic stress.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-010-1060-7