Antiamnestic Effects of Antibodies to Glutamate in Experimental Alzheimer's Disease

Experiments on rats showed that neurodegenerative brain damage caused by administration of neurotoxic fragment of β-amyloid protein Aβ₂₅₋₃₅ in a dose of 2 μg into Meynert giant cell nucleus leads to long-term memory impairment in rats. Intranasal administration of antibodies to glutamate in a dose o...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2010-12, Vol.150 (1), p.23-25
Hauptverfasser:	Gorbatov, V. Yu, Trekova, N. A, Fomina, V. G, Davydova, T. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Alzheimer Disease - chemically induced Alzheimer Disease - drug therapy Alzheimer's disease Amnesia - chemically induced Amnesia - drug therapy Amyloid beta-Peptides - toxicity Amyloid beta-protein amyloid peptide Aβ Animals Antibodies Antibodies - administration & dosage Antibodies - immunology Antibodies - therapeutic use antibodies to glutamate Avoidance Learning - drug effects Biomedical and Life Sciences Biomedicine Cell Biology cognitive impairments Glutamate Glutamic Acid - immunology Internal Medicine Laboratory Medicine Male Memory, Long-Term - drug effects Meynert giant cell nucleus Pathology Rats Rats, Wistar Viral antibodies
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Zusammenfassung:	Experiments on rats showed that neurodegenerative brain damage caused by administration of neurotoxic fragment of β-amyloid protein Aβ₂₅₋₃₅ in a dose of 2 μg into Meynert giant cell nucleus leads to long-term memory impairment in rats. Intranasal administration of antibodies to glutamate in a dose of 300 μg/kg 1 h after damage restores learning capacity of the experimental animals in the conditioned passive avoidance paradigm.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-010-1058-1