Analysis of association between bleomycin hydrolase and apolipoprotein E polymorphism in Alzheimer’s disease

Alzheimer’s disease (AD) is the leading cause of dementia. Several studies indicate a possible relationship between different genes and Alzheimer’s disease. To further investigate, we have analyzed the association between the bleomycin hydrolase (BLMH) and apolipoprotein E (ApoE) polymorphisms in 93...

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Veröffentlicht in:	Neurological sciences 2010-12, Vol.31 (6), p.687-691
Hauptverfasser:	Smach, Mohamed Ali, Charfeddine, Bassem, Lammouchi, Turkia, Othman, Leila Ben, Letaief, Afef, Nafati, Souhir, Dridi, Hedi, Bennamou, Soufien, Limem, Khalifa
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - enzymology Alzheimer Disease - genetics Apolipoprotein E4 - genetics Apolipoproteins E - genetics Cysteine Endopeptidases - genetics Female Genetic Carrier Screening Genetic Predisposition to Disease - genetics Humans Male Medicine Medicine & Public Health Neurology Neuroradiology Neurosciences Neurosurgery Original Article Polymorphism, Genetic - genetics Psychiatry Tunisia
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Zusammenfassung:	Alzheimer’s disease (AD) is the leading cause of dementia. Several studies indicate a possible relationship between different genes and Alzheimer’s disease. To further investigate, we have analyzed the association between the bleomycin hydrolase (BLMH) and apolipoprotein E (ApoE) polymorphisms in 93 AD patients and age- and sex-matched 113 controls from the Tunisian population. The frequency of ApoE epsilon 4 allele was found to differ significantly in AD patients compared to the control [29.5% vs. 8.8 ( χ 2 = 26, df = 1, p
ISSN:	1590-1874 1590-3478
DOI:	10.1007/s10072-010-0234-4