Olfactory ensheathing cells moderate nuclear factor kappaB translocation in astrocytes

Olfactory ensheathing cells moderate nuclear factor kappaB translocation in astrocytes

Nuclear factor kappaB (NFκB) is a key transcriptional regulator of inflammatory genes. We investigated the modulatory effects of olfactory ensheathing cells (OECs), microglia and meningeal fibroblasts on translocation of NFκB to astrocyte nuclei. The percentage of activated astrocytes in co-cultures...

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Veröffentlicht in:Molecular and cellular neuroscience 2011-01, Vol.46 (1), p.213-221
Hauptverfasser: Hale, David M., Ray, Shannon, Leung, Jacqueline Y., Holloway, Adele F., Chung, Roger S., West, Adrian K., Chuah, Meng Inn
Format: Artikel
Sprache:eng
Schlagworte:
Activation of astrocytes
Animals
Astrocytes - cytology
Astrocytes - drug effects
Astrocytes - metabolism
Calcium - metabolism
Cell Nucleus - metabolism
Cells, Cultured
Coculture Techniques
Fibroblasts - cytology
Fibroblasts - drug effects
Fibroblasts - physiology
Granulocyte-Macrophage Colony-Stimulating Factor - genetics
Granulocyte-Macrophage Colony-Stimulating Factor - metabolism
Inflammation
Insulin-Like Growth Factor I - metabolism
Ionophores - pharmacology
Meninges - cytology
Microglia
Microglia - cytology
Microglia - drug effects
Microglia - physiology
NF-kappa B - metabolism
Nuclear factor kappaB
Olfactory ensheathing cells
Protein Transport - physiology
Rats
Rats, Wistar
Schwann Cells - cytology
Schwann Cells - physiology
Tetradecanoylphorbol Acetate - pharmacology
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Zusammenfassung:Nuclear factor kappaB (NFκB) is a key transcriptional regulator of inflammatory genes. We investigated the modulatory effects of olfactory ensheathing cells (OECs), microglia and meningeal fibroblasts on translocation of NFκB to astrocyte nuclei. The percentage of activated astrocytes in co-cultures with OECs was significantly less than for co-cultures with microglia (p
ISSN:1044-7431
1095-9327
DOI:10.1016/j.mcn.2010.09.004