Modulation of Oscillatory Synchronization in an Interneuronal Network under the Influence of Tonic GABA-ergic Inhibition: a Model Study
The influence of a tonic GABA-ergic current on the processes of network synchronization was examined using a computer model of the neural network with shunting GABA-ergic synapses and tonic excitation that initiated spiking. The tonic inhibitory current was characterized by two parameters, the rever...
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Veröffentlicht in: | Neurophysiology (New York) 2011-03, Vol.42 (5), p.318-324 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The influence of a tonic GABA-ergic current on the processes of network synchronization was examined using a computer model of the neural network with shunting GABA-ergic synapses and tonic excitation that initiated spiking. The tonic inhibitory current was characterized by two parameters, the reversal potential and the conductance introduced. We found that tonic current with a reversal potential more negative than the threshold for spike generation reduces the network spiking frequency and synchronization. A monotonic decrease in the network synchronization with augmentation of the tonic current conductance was shown. We also found that a particular range of tonic current conductance leads to a bistable character of the network dynamics. Depending on the initial conditions of the network examined, spontaneous synchronous oscillations similar to epileptiform activity could appear. |
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ISSN: | 0090-2977 1573-9007 |
DOI: | 10.1007/s11062-011-9165-9 |