Modulation of Oscillatory Synchronization in an Interneuronal Network under the Influence of Tonic GABA-ergic Inhibition: a Model Study

The influence of a tonic GABA-ergic current on the processes of network synchronization was examined using a computer model of the neural network with shunting GABA-ergic synapses and tonic excitation that initiated spiking. The tonic inhibitory current was characterized by two parameters, the rever...

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Veröffentlicht in:Neurophysiology (New York) 2011-03, Vol.42 (5), p.318-324
Hauptverfasser: Kochubey, S. A, Savtchenko, L. P, Sem'yanov, A. V
Format: Artikel
Sprache:eng
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Zusammenfassung:The influence of a tonic GABA-ergic current on the processes of network synchronization was examined using a computer model of the neural network with shunting GABA-ergic synapses and tonic excitation that initiated spiking. The tonic inhibitory current was characterized by two parameters, the reversal potential and the conductance introduced. We found that tonic current with a reversal potential more negative than the threshold for spike generation reduces the network spiking frequency and synchronization. A monotonic decrease in the network synchronization with augmentation of the tonic current conductance was shown. We also found that a particular range of tonic current conductance leads to a bistable character of the network dynamics. Depending on the initial conditions of the network examined, spontaneous synchronous oscillations similar to epileptiform activity could appear.
ISSN:0090-2977
1573-9007
DOI:10.1007/s11062-011-9165-9