Expression of Molecular Markers in the Tumor and Survival Prognosis in Osteosarcoma

Immunohistochemical study of p53, VEGF, Flt-1/VEGFR1 Ab-1, EGFR, HER-2/neu, Bax, and Cox-2 expression in osteosarcomas was carried out in 40 patients aged 16-70 years. Expression of p53 was detected in 27.5% tumors, VEGF in 15%, Flt-1/VEGFR1 Ab-1 in 97.5%, EGFR in 52.5%, HER-2/neu in 32.5%, Bax in 7...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2010-12, Vol.150 (2), p.237-242
Hauptverfasser:	Boulytcheva, I. V, Soloviev, Yu. N, Kushlinskii, N. E, Mahson, A. N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antibodies - metabolism Antigen-antibody reactions bcl-2-Associated X Protein - metabolism Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Bone Neoplasms - metabolism Bone Neoplasms - mortality Bone Neoplasms - physiopathology Cell Biology Cyclooxygenase 2 - metabolism EGFR ErbB Receptors - metabolism expression Flt-1/VEGFR1 Ab-1 Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Neoplastic - physiology HER-2/neu Humans Immunohistochemistry Internal Medicine Laboratory Medicine Middle Aged Osteosarcoma Osteosarcoma - metabolism Osteosarcoma - mortality Osteosarcoma - physiopathology p53 Pathology Prognosis Receptor, ErbB-2 - metabolism Tumor proteins Tumor Suppressor Protein p53 - metabolism Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-1 - metabolism VEGF
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Zusammenfassung:	Immunohistochemical study of p53, VEGF, Flt-1/VEGFR1 Ab-1, EGFR, HER-2/neu, Bax, and Cox-2 expression in osteosarcomas was carried out in 40 patients aged 16-70 years. Expression of p53 was detected in 27.5% tumors, VEGF in 15%, Flt-1/VEGFR1 Ab-1 in 97.5%, EGFR in 52.5%, HER-2/neu in 32.5%, Bax in 77.8%, and Cox-2 in 32.3% tumors. Multifactorial analysis showed that the expression of HER-2/neu (p=0.004), p53 (p=0.01), and Cox-2 (p=0.04) in osteosarcomas significantly correlated with unfavorable prognosis for overall survival, while HER-2/neu (p=0.02) and Cox-2 (p=0.003) with relapse-free survival. Analysis of HER-2/neu, p53, and Cox-2 expression in the primary tumor should be taken into consideration in the treatment of patients with osteosarcoma.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-010-1114-x