Evaluation Of 5-hydroxy-2,3-diaryl (substituted)-cyclopent-2-en-1-ones as cis-restricted analogues of combretastatin A-4 as novel anti angiogenic and anticancer agents

Summary Two potent cis -restricted CA-4 analogues 11 and 42 belonging to 2,3-diaryl-5-hydroxycyclopent-2-en-1-one class were evaluated for anticancer and anti angiogenic activity. The compound 42 displayed potent cytotoxic activity (IC 50

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Bibliographische Detailangaben
Veröffentlicht in:	Investigational new drugs 2010-08, Vol.28 (4), p.363-380
Hauptverfasser:	Sanna, Vinod Kumar, Jaggi, Manu, Kumar, Vadlapudi, Burman, Anand C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Animals Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Binding sites Blood vessels Cancer Caspase 3 - metabolism Cell adhesion & migration Cell cycle Cell growth Cell Line Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cytogenetics Cytotoxicity Diabetic retinopathy Drug dosages Drug Screening Assays, Antitumor - methods Experiments Fibroblasts Genes Growth factors Humans Leukemia Medicine Medicine & Public Health Metabolism Mice Mice, Nude Oncology Ovaries Pharmacology/Toxicology Preclinical Studies Prostate R&D Research & development Stilbenes - chemistry Stilbenes - pharmacology Structure-Activity Relationship Toxicity Tumors Wound Healing - drug effects
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Beschreibung
Zusammenfassung:	Summary Two potent cis -restricted CA-4 analogues 11 and 42 belonging to 2,3-diaryl-5-hydroxycyclopent-2-en-1-one class were evaluated for anticancer and anti angiogenic activity. The compound 42 displayed potent cytotoxic activity (IC 50
ISSN:	0167-6997 1573-0646
DOI:	10.1007/s10637-009-9256-2