Selective peroxisome proliferator-activated receptor d isosteric selenium agonists as potent anti-atherogenic agents in vivo

We report the synthesis and in vivo activity of a novel anti-atherogenic agent, isosteric selenium PPARd-selective ligand. This ligand did not cause significant body or liver weight changes and did not have obvious adverse effects on intestinal polyp formation. Our overall results clearly demonstrate that PPARd is a viable drug candidate for targeting and treating atherosclerosis.