Synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1 H)ones as MCH-1 antagonists for the treatment of obesity

The synthesis and SAR of 4-aryl-1-(indazol-5-yl)pyridin-2(1 H)ones as MCH-1 antagonists are described. A new series of 4-aryl-1-(indazol-5-yl)pyridin-2(1 H)ones possessing MCH-1 receptor antagonism is presented. Suzuki coupling of boronic acids with key triflate 6 allowed rapid generation of a range of analogs. The SAR of the MCH-1 receptor was explored with a variety of aryl and heterocyclic moieties. Selected compounds were studied in a five-day diet induced obese mouse model to evaluate their potential use as weight loss agents.