Relation of Impaired Coronary Microcirculation to Increased Urine Albumin Excretion in Patients With Systemic Hypertension and No Epicardial Coronary Arterial Narrowing

Coronary flow reserve (CFR) is impaired and urinary albumin excretion is increased in patients with essential hypertension. Our aim was to investigate the associations between CFR and cardiac and renal damage in hypertensives. For this purpose we studied 37 never-treated hypertensives (57.9 years ol...

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Veröffentlicht in:The American journal of cardiology 2012-04, Vol.109 (7), p.1026-1030
Hauptverfasser: Tsiachris, Dimitris, MD, Tsioufis, Costas, MD, Dimitriadis, Kyriakos, MD, Syrseloudis, Dimitris, MD, Rousos, Dimitris, MD, Kasiakogias, Alexandros, MD, Papademetriou, Vasilios, MD, Tousoulis, Dimitris, MD, Stefanadis, Christodoulos, MD
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Sprache:eng
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Zusammenfassung:Coronary flow reserve (CFR) is impaired and urinary albumin excretion is increased in patients with essential hypertension. Our aim was to investigate the associations between CFR and cardiac and renal damage in hypertensives. For this purpose we studied 37 never-treated hypertensives (57.9 years old, 16 men) without chest pain but with a positive ischemia stress test result and normal coronary arteries on coronary angiogram. CFR was calculated by a 0.014-inch Doppler guidewire (Flowire, Volcano, San Diego) in the left anterior descending artery in response to bolus intracoronary administration of adenosine (60 μg) as the ratio of hyperemic to basal average peak velocity of the distal vessel. All participants underwent complete echocardiographic study including left ventricular diastolic function evaluation by tissue Doppler imaging (peak early diastolic velocity/peak atrial systolic velocity) and determination of the albumin-to-creatinine ratio (ACR). Hypertensives with low CFR (
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2011.11.035