Interrelation of Cell Apoptosis and Proliferation in the Thymus during Its Involution

In people over 60 years, thymocytes contain proliferation protein Ki67 and proapoptotic protein P53. During aging, apoptosis of thymus cell prevails over proliferation, though thymocytes retain proliferative capacity even in long-livers.

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Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2011-08, Vol.151 (4), p.460-462
Hauptverfasser:	Linkova, N. S., Polyakova, V. O., Kvetnoy, I. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Apoptosis Biomedical and Life Sciences Biomedicine Cell Biology Cell Proliferation Humans Internal Medicine Ki-67 Antigen - metabolism Laboratory Medicine Middle Aged Pathology Thymus Gland - cytology Thymus Gland - metabolism Tumor proteins Tumor Suppressor Protein p53 - metabolism
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Beschreibung
Zusammenfassung:	In people over 60 years, thymocytes contain proliferation protein Ki67 and proapoptotic protein P53. During aging, apoptosis of thymus cell prevails over proliferation, though thymocytes retain proliferative capacity even in long-livers.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-011-1356-2