DNA repair gene XPD and XRCC1 polymorphisms and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma
Abstract The aim of the study is to investigate association between DNA repair gene XPD and XRCC1 polymorphisms and febrile neutropenia (FN) and mucositis. The study population consisted of 29 children with Burkitt lymphoma and 61 children with acute lymphoblastic leukemia. Analysis revealed that XR...
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| Veröffentlicht in: | Leukemia research 2012-05, Vol.36 (5), p.565-569 |
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| creator | Özdemir, Nihal Celkan, Tiraje Barış, Safa Batar, Bahadır Güven, Mehmet |
| description | Abstract The aim of the study is to investigate association between DNA repair gene XPD and XRCC1 polymorphisms and febrile neutropenia (FN) and mucositis. The study population consisted of 29 children with Burkitt lymphoma and 61 children with acute lymphoblastic leukemia. Analysis revealed that XRCC1194Trp allele showed a protective effect against longer FN and mucositis. There was also statistically increased risk for severe mucositis in patients with XRCC1Arg399Gln polymorphism. There are no studies that have examined this relationship before. Further studies with larger cohorts are needed to clarify the association. |
| doi_str_mv | 10.1016/j.leukres.2011.10.012 |
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The study population consisted of 29 children with Burkitt lymphoma and 61 children with acute lymphoblastic leukemia. Analysis revealed that XRCC1194Trp allele showed a protective effect against longer FN and mucositis. There was also statistically increased risk for severe mucositis in patients with XRCC1Arg399Gln polymorphism. There are no studies that have examined this relationship before. Further studies with larger cohorts are needed to clarify the association.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/j.leukres.2011.10.012</identifier><identifier>PMID: 22047709</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Acute lymphatic leukemia ; Adolescent ; Burkitt Lymphoma - genetics ; Burkitt's lymphoma ; Child ; Child, Preschool ; Children ; DNA repair ; DNA-Binding Proteins - genetics ; Febrile neutropenia ; Female ; Fever - etiology ; Fever - genetics ; Gene polymorphism ; Hematology, Oncology and Palliative Medicine ; Humans ; Infant ; Lymphoma ; Male ; Mucositis ; Mucositis - etiology ; Mucositis - genetics ; Neutropenia ; Neutropenia - etiology ; Neutropenia - genetics ; Polymorphism, Genetic ; Population studies ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Risk ; X-ray Repair Cross Complementing Protein 1 ; Xeroderma Pigmentosum Group D Protein - genetics ; XPD protein ; XRCC1 and XPD polymorphisms ; XRCC1 protein</subject><ispartof>Leukemia research, 2012-05, Vol.36 (5), p.565-569</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-cff8b2004351992cc85b77b571789fad3d2eb99acad7423cafc6d77daa4b72783</citedby><cites>FETCH-LOGICAL-c452t-cff8b2004351992cc85b77b571789fad3d2eb99acad7423cafc6d77daa4b72783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0145212611005091$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22047709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Özdemir, Nihal</creatorcontrib><creatorcontrib>Celkan, Tiraje</creatorcontrib><creatorcontrib>Barış, Safa</creatorcontrib><creatorcontrib>Batar, Bahadır</creatorcontrib><creatorcontrib>Güven, Mehmet</creatorcontrib><title>DNA repair gene XPD and XRCC1 polymorphisms and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>Abstract The aim of the study is to investigate association between DNA repair gene XPD and XRCC1 polymorphisms and febrile neutropenia (FN) and mucositis. The study population consisted of 29 children with Burkitt lymphoma and 61 children with acute lymphoblastic leukemia. Analysis revealed that XRCC1194Trp allele showed a protective effect against longer FN and mucositis. There was also statistically increased risk for severe mucositis in patients with XRCC1Arg399Gln polymorphism. There are no studies that have examined this relationship before. Further studies with larger cohorts are needed to clarify the association.</description><subject>Acute lymphatic leukemia</subject><subject>Adolescent</subject><subject>Burkitt Lymphoma - genetics</subject><subject>Burkitt's lymphoma</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>DNA repair</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Febrile neutropenia</subject><subject>Female</subject><subject>Fever - etiology</subject><subject>Fever - genetics</subject><subject>Gene polymorphism</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Infant</subject><subject>Lymphoma</subject><subject>Male</subject><subject>Mucositis</subject><subject>Mucositis - etiology</subject><subject>Mucositis - genetics</subject><subject>Neutropenia</subject><subject>Neutropenia - etiology</subject><subject>Neutropenia - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Population studies</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Risk</subject><subject>X-ray Repair Cross Complementing Protein 1</subject><subject>Xeroderma Pigmentosum Group D Protein - genetics</subject><subject>XPD protein</subject><subject>XRCC1 and XPD polymorphisms</subject><subject>XRCC1 protein</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2P0zAQhi0EYsvCTwD5BpcU24nj-AJadfmSVoD4kPZmOfaEuk3srJ2AeueH42wLBw5wsvTqmXc88w5CjylZU0Lr57t1D_M-QlozQmnW1oSyO2hFG1EWvCn5XbQitOIFo6w-Qw9S2hFCuKTyPjpjjFRCELlCPy_fX-AIo3YRfwMP-PrjJdbe4utPmw3FY-gPQ4jj1qUh3erTFnB0aY9Dhztoo-sBe5inGEbwTt8yw2xCcpNL2Hlstq63ETz-4aYtXj4Nw4nL3uM2DPohutfpPsGj03uOvr5-9WXztrj68Obd5uKqMBVnU2G6rmkZIVXJqZTMmIa3QrRcUNHITtvSMmil1EZbUbHS6M7UVgirddUKJpryHD09-o4x3MyQJjW4ZKDvtYcwJyWrRpKaU5HJZ_8kcwSUUUKaKqP8iJoYUorQqTG6QcdDhhauVjt1ikotUS1yjirXPTm1mNsB7J-q39lk4OURgLyS7w6iSsaBN2BdBDMpG9x_W7z4y8H0zjuj-z0cIO3CHH3et6IqMUXU5-VelnOheTJOJC1_AUmyvWc</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Özdemir, Nihal</creator><creator>Celkan, Tiraje</creator><creator>Barış, Safa</creator><creator>Batar, Bahadır</creator><creator>Güven, Mehmet</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>DNA repair gene XPD and XRCC1 polymorphisms and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma</title><author>Özdemir, Nihal ; Celkan, Tiraje ; Barış, Safa ; Batar, Bahadır ; Güven, Mehmet</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-cff8b2004351992cc85b77b571789fad3d2eb99acad7423cafc6d77daa4b72783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acute lymphatic leukemia</topic><topic>Adolescent</topic><topic>Burkitt Lymphoma - genetics</topic><topic>Burkitt's lymphoma</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>DNA repair</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Febrile neutropenia</topic><topic>Female</topic><topic>Fever - etiology</topic><topic>Fever - genetics</topic><topic>Gene polymorphism</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Infant</topic><topic>Lymphoma</topic><topic>Male</topic><topic>Mucositis</topic><topic>Mucositis - etiology</topic><topic>Mucositis - genetics</topic><topic>Neutropenia</topic><topic>Neutropenia - etiology</topic><topic>Neutropenia - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Population studies</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Risk</topic><topic>X-ray Repair Cross Complementing Protein 1</topic><topic>Xeroderma Pigmentosum Group D Protein - genetics</topic><topic>XPD protein</topic><topic>XRCC1 and XPD polymorphisms</topic><topic>XRCC1 protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Özdemir, Nihal</creatorcontrib><creatorcontrib>Celkan, Tiraje</creatorcontrib><creatorcontrib>Barış, Safa</creatorcontrib><creatorcontrib>Batar, Bahadır</creatorcontrib><creatorcontrib>Güven, Mehmet</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Özdemir, Nihal</au><au>Celkan, Tiraje</au><au>Barış, Safa</au><au>Batar, Bahadır</au><au>Güven, Mehmet</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA repair gene XPD and XRCC1 polymorphisms and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>36</volume><issue>5</issue><spage>565</spage><epage>569</epage><pages>565-569</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><abstract>Abstract The aim of the study is to investigate association between DNA repair gene XPD and XRCC1 polymorphisms and febrile neutropenia (FN) and mucositis. The study population consisted of 29 children with Burkitt lymphoma and 61 children with acute lymphoblastic leukemia. Analysis revealed that XRCC1194Trp allele showed a protective effect against longer FN and mucositis. There was also statistically increased risk for severe mucositis in patients with XRCC1Arg399Gln polymorphism. There are no studies that have examined this relationship before. Further studies with larger cohorts are needed to clarify the association.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>22047709</pmid><doi>10.1016/j.leukres.2011.10.012</doi><tpages>5</tpages></addata></record> |
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| subjects | Acute lymphatic leukemia Adolescent Burkitt Lymphoma - genetics Burkitt's lymphoma Child Child, Preschool Children DNA repair DNA-Binding Proteins - genetics Febrile neutropenia Female Fever - etiology Fever - genetics Gene polymorphism Hematology, Oncology and Palliative Medicine Humans Infant Lymphoma Male Mucositis Mucositis - etiology Mucositis - genetics Neutropenia Neutropenia - etiology Neutropenia - genetics Polymorphism, Genetic Population studies Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Risk X-ray Repair Cross Complementing Protein 1 Xeroderma Pigmentosum Group D Protein - genetics XPD protein XRCC1 and XPD polymorphisms XRCC1 protein |
| title | DNA repair gene XPD and XRCC1 polymorphisms and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma |
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