DNA repair gene XPD and XRCC1 polymorphisms and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma

Abstract The aim of the study is to investigate association between DNA repair gene XPD and XRCC1 polymorphisms and febrile neutropenia (FN) and mucositis. The study population consisted of 29 children with Burkitt lymphoma and 61 children with acute lymphoblastic leukemia. Analysis revealed that XR...

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Veröffentlicht in:	Leukemia research 2012-05, Vol.36 (5), p.565-569
Hauptverfasser:	Özdemir, Nihal, Celkan, Tiraje, Barış, Safa, Batar, Bahadır, Güven, Mehmet
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphatic leukemia Adolescent Burkitt Lymphoma - genetics Burkitt's lymphoma Child Child, Preschool Children DNA repair DNA-Binding Proteins - genetics Febrile neutropenia Female Fever - etiology Fever - genetics Gene polymorphism Hematology, Oncology and Palliative Medicine Humans Infant Lymphoma Male Mucositis Mucositis - etiology Mucositis - genetics Neutropenia Neutropenia - etiology Neutropenia - genetics Polymorphism, Genetic Population studies Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Risk X-ray Repair Cross Complementing Protein 1 Xeroderma Pigmentosum Group D Protein - genetics XPD protein XRCC1 and XPD polymorphisms XRCC1 protein
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Zusammenfassung:	Abstract The aim of the study is to investigate association between DNA repair gene XPD and XRCC1 polymorphisms and febrile neutropenia (FN) and mucositis. The study population consisted of 29 children with Burkitt lymphoma and 61 children with acute lymphoblastic leukemia. Analysis revealed that XRCC1194Trp allele showed a protective effect against longer FN and mucositis. There was also statistically increased risk for severe mucositis in patients with XRCC1Arg399Gln polymorphism. There are no studies that have examined this relationship before. Further studies with larger cohorts are needed to clarify the association.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2011.10.012