Hepatogenic Potential of Human Bone Marrow and Umbilical Cord Blood Mesenchymal Stem Cells

Conditions of human BM and umbilical cord blood MSC in vitro differentiation in the hepatogenic direction were studied. Changes in cell morphology, phenotype, acquisition of the capacity to produce albumin and accumulate glycogen, express cytokeratin, alkaline phosphatase, and albumin mRNA indicated...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2011-05, Vol.151 (1), p.142-149
Hauptverfasser:	Kosmacheva, S. M., Seviaryn, I. N., Goncharova, N. V., Petyovka, N. V., Potapnev, M. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumin Albumins - biosynthesis Alkaline phosphatase Alkaline Phosphatase - biosynthesis Antigens, CD - biosynthesis Biomarkers - metabolism Biomedical and Life Sciences Biomedicine Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Cell Biology Cell Differentiation - drug effects Cells, Cultured Cytokeratin Cytology Differentiation Fetal Blood - cytology Fetal Blood - metabolism Flow Cytometry Glucose metabolism Glycogen Glycogen - biosynthesis Hepatocytes - cytology Hepatocytes - metabolism Humans Immunophenotyping Intercellular Signaling Peptides and Proteins - pharmacology Internal Medicine Keratin Keratins - biosynthesis Laboratory Medicine Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism Mesenchyme mRNA Pathology RNA RNA, Messenger - biosynthesis Stem cells Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine) Umbilical cord
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Beschreibung
Zusammenfassung:	Conditions of human BM and umbilical cord blood MSC in vitro differentiation in the hepatogenic direction were studied. Changes in cell morphology, phenotype, acquisition of the capacity to produce albumin and accumulate glycogen, express cytokeratin, alkaline phosphatase, and albumin mRNA indicated that BM and umbilical cord blood MSC differentiated in vitro into immature hepatocyte-like cells.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-011-1276-1