In Vitro and In Vivo Uncaging and Bioluminescence Imaging by Using Photocaged Upconversion Nanoparticles

In Vitro and In Vivo Uncaging and Bioluminescence Imaging by Using Photocaged Upconversion Nanoparticles

Trading up: A bioimaging system that is based on caged D‐luciferin/upconversion nanoparticle conjugate has been developed. The nanoparticles upconvert near‐infrared light into UV light, which triggers the photorelease of D‐luciferin (see scheme) and leads to enhanced fluorescence and bioluminescence...

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Veröffentlicht in:Angewandte Chemie International Edition 2012-03, Vol.51 (13), p.3125-3129
Hauptverfasser: Yang, Yanmei, Shao, Qing, Deng, Renren, Wang, Chao, Teng, Xue, Cheng, Kai, Cheng, Zhen, Huang, Ling, Liu, Zhuang, Liu, Xiaogang, Xing, Bengang
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Benzothiazoles - analysis
bioluminescence
Cell Line, Tumor
Cell Survival
D-luciferin
Humans
Luminescence
Luminescent Agents - analysis
Mice
Microscopy - methods
nanoparticles
Nanoparticles - analysis
Photochemical Processes
photochemistry
upconversion
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Beschreibung
Zusammenfassung:Trading up: A bioimaging system that is based on caged D‐luciferin/upconversion nanoparticle conjugate has been developed. The nanoparticles upconvert near‐infrared light into UV light, which triggers the photorelease of D‐luciferin (see scheme) and leads to enhanced fluorescence and bioluminescence signals in vitro and in vivo. The use of near‐infrared light enables deep penetration into tissue in vivo with minimum cellular damage.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201107919