Pd(II)-catalyzed direct C5-arylation of azole-4-carboxylates through double C-H bond cleavage

Pd(II)-catalyzed direct C5-arylation of azole-4-carboxylates through double C-H bond cleavage

The first palladium-catalyzed direct C5-arylation of azole-4-carboxylates with simple unactivated arenes through double C-H bond cleavage is realized. This protocol provided a straightforward access to diverse 5-arylsubstituted azole-4-carboxylic derivatives with good functional group tolerance.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-01, Vol.48 (31), p.3763-3765
Hauptverfasser: Li, Ziyuan, Ma, Ling, Xu, Jinyi, Kong, Lingyi, Wu, Xiaoming, Yao, Hequan
Format: Artikel
Sprache:eng
Schlagworte:
Azoles - chemistry
Carboxylic Acids - chemistry
Catalysis
Palladium - chemistry
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Zusammenfassung:The first palladium-catalyzed direct C5-arylation of azole-4-carboxylates with simple unactivated arenes through double C-H bond cleavage is realized. This protocol provided a straightforward access to diverse 5-arylsubstituted azole-4-carboxylic derivatives with good functional group tolerance.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc00081d