Antibody-Based Immunotherapy of Cancer

By targeting surface antigens expressed on tumor cells, monoclonal antibodies have demonstrated efficacy as cancer therapeutics. Recent successful antibody-based strategies have focused on enhancing antitumor immune responses by targeting immune cells, irrespective of tumor antigens. We discuss thes...

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Veröffentlicht in:	Cell 2012-03, Vol.148 (6), p.1081-1084
Hauptverfasser:	Weiner, Louis M., Murray, Joseph C., Shuptrine, Casey W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use Antigen (tumor-associated) Antitumor activity Cancer Cancer Vaccines - immunology Cancer Vaccines - therapeutic use Humans Immune response Immunotherapy Monoclonal antibodies Neoplasms - immunology Neoplasms - therapy surface antigens Tumor cells Tumors
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Beschreibung
Zusammenfassung:	By targeting surface antigens expressed on tumor cells, monoclonal antibodies have demonstrated efficacy as cancer therapeutics. Recent successful antibody-based strategies have focused on enhancing antitumor immune responses by targeting immune cells, irrespective of tumor antigens. We discuss these innovative strategies and propose how they will impact the future of antibody-based cancer therapy.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/j.cell.2012.02.034