Antibody levels against B. pertussis in neonates measured in dried blood spots

Highlights ► Whooping cough is a contagious disease with a rising incidence ► Collection of small blood samples in small children on filter paper (Guthrie card) is feasible and less invasive than venous puncture. ► Our results show that maternal IgG-PT levels against B. pertussis measured in cord bl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2012-03, Vol.30 (16), p.2697-2700
Hauptverfasser:	van Ommen, C.C.N, Elvers, L.H, Notermans, D.W, van Huisseling, J.C.M, Teunis, P.F.M, Versteegh, F.G.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology antibodies Antibodies, Bacterial - blood Antibodies, Bacterial - immunology blood serum Blood spot Bordetella pertussis Bordetella pertussis - immunology Calibration Cord blood correlation Dried Blood Spot Testing Enzyme-Linked Immunosorbent Assay Fetal Blood - chemistry Filter paper Guthrie card Hospitals Humans IgG-PT Immunoglobulin G - blood Immunoglobulin G - immunology Infant, Newborn mothers Neonates Netherlands patients Pertussis Pertussis Toxin - blood Pertussis Toxin - immunology Prospective Studies Regression analysis Toxins Umbilical cord vaccines Whooping Cough - diagnosis Whooping Cough - immunology Whooping Cough - microbiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights ► Whooping cough is a contagious disease with a rising incidence ► Collection of small blood samples in small children on filter paper (Guthrie card) is feasible and less invasive than venous puncture. ► Our results show that maternal IgG-PT levels against B. pertussis measured in cord blood applied to Guthrie cards and calibrated against blood spot calibrators show good agreement with IgG-PT levels in cord serum. ► This offers practical tools for future studies concerning B. pertussis antibodies especially in young children.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.12.087