Modelling the long-term persistence of neutralizing antibody in adults after one dose of live attenuated Japanese encephalitis chimeric virus vaccine

Highlights ► We modelled antibody persistence after Japanese encephalitis vaccination. ► We considered vaccination with a live attenuated chimeric virus vaccine. ► We used 5 year follow-up data from adults having received a single vaccine dose. ► An initial period of rapid decline followed by much s...

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Veröffentlicht in:	Vaccine 2012-03, Vol.30 (15), p.2510-2515
Hauptverfasser:	Desai, Kamal, Coudeville, L, Bailleux, F
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Allergy and Immunology Animal vaccines Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Antibody persistence chimerism Confidence intervals data collection Decision making Disease Duration of protection encephalitis Encephalitis Viruses, Japanese - immunology Encephalitis, Japanese - prevention & control Humans Immunization Japanese encephalitis Japanese Encephalitis Vaccines - administration & dosage Models, Statistical neutralizing antibodies Population Statistical model statistical models vaccination Vaccines Vaccines, Attenuated - administration & dosage Vector-borne diseases viruses
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Beschreibung
Zusammenfassung:	Highlights ► We modelled antibody persistence after Japanese encephalitis vaccination. ► We considered vaccination with a live attenuated chimeric virus vaccine. ► We used 5 year follow-up data from adults having received a single vaccine dose. ► An initial period of rapid decline followed by much slower decline were identified. ► This analysis suggests that vaccine protects most adults for at least 10 years.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2012.02.005