Serum levels of protein S100B predict intracranial lesions in mild head injury

This study was aimed to assess whether serum S100B levels at emergency department admission can be used to omit unnecessary computed tomography (CT) in patients with minor head injury (MHI). Sixty consecutive patients with recent MHI were included in this study. Serum S100B measurement and CT scanni...

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Veröffentlicht in:	Clinical biochemistry 2012-04, Vol.45 (6), p.408-411
Hauptverfasser:	Cervellin, Gianfranco, Benatti, Mario, Carbucicchio, Andrea, Mattei, Loris, Cerasti, Davide, Aloe, Rosalia, Lippi, Giuseppe
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adult and adolescent clinical studies Aged Aged, 80 and over Area Under Curve Biological and medical sciences Brain injury Computed tomography Craniocerebral Trauma - blood Craniocerebral Trauma - diagnostic imaging Craniocerebral Trauma - pathology Female Head trauma Humans Injuries of the nervous system and the skull. Diseases due to physical agents Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Nerve Growth Factors - blood Organic mental disorders. Neuropsychology Prospective Studies Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radiography ROC Curve S100 Calcium Binding Protein beta Subunit S100 Proteins - blood S100B Traumas. Diseases due to physical agents Young Adult
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Zusammenfassung:	This study was aimed to assess whether serum S100B levels at emergency department admission can be used to omit unnecessary computed tomography (CT) in patients with minor head injury (MHI). Sixty consecutive patients with recent MHI were included in this study. Serum S100B measurement and CT scanning were performed in all patients within 3h from head injury. A positive CT scan was present in 20 out of 60 subjects. Significantly higher values of protein S100B were found in CT positive than in CT negative patients (1.35 versus 0.48μg/L; p
ISSN:	0009-9120 1873-2933
DOI:	10.1016/j.clinbiochem.2012.01.006