Peptide-Antibody Complex as Handle for Single-Molecule Cut & Paste

Molecule‐by‐molecule arrangement of proteins, for example, in enzymatic networks of predefined composition and proximity, is a major goal that may be accomplished by the single‐molecule cut‐and‐paste technique (SMC&P). For this purpose, co‐expressed anchors and handles as protein tags should be employed. As a first step in this direction, the authors develop an SMC&P design which exploits an antibody–peptide complex as a molecular handle.