Investigation of encapsulation of insulin biotemplate within C-methylresorcin[4]arenes

Investigation of encapsulation of insulin biotemplate within C-methylresorcin[4]arenes

Solution structure of insulin templated C-methyl resorcin[4]arene nanocapsules has been investigated using neutron scattering. The insulin biotemplate has enhanced the limits of encapsulation and enabled formation of a larger spherical molecular host.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2012-04, Vol.48 (30), p.3599-3601
Hauptverfasser: Kumari, Harshita, Kline, Steven R, Atwood, Jerry L
Format: Artikel
Sprache:eng
Schlagworte:
Calixarenes - chemistry
Insulin Lispro - chemistry
Nanocapsules - chemistry
Neutron Diffraction
Scattering, Small Angle
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Zusammenfassung:Solution structure of insulin templated C-methyl resorcin[4]arene nanocapsules has been investigated using neutron scattering. The insulin biotemplate has enhanced the limits of encapsulation and enabled formation of a larger spherical molecular host.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc18071e