Riboflavin-UVA-Induced Corneal Collagen Cross-linking in Pediatric Patients

Riboflavin-UVA-Induced Corneal Collagen Cross-linking in Pediatric Patients

PURPOSE:Evaluation of stability and functional response after riboflavin-UVA–induced cross-linking in a population of patients younger than 18 years with progressive keratoconus after 36 months of follow-up. METHODS:Prospective nonrandomized phase II open trial conducted at the Department of Ophthal...

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Veröffentlicht in:Cornea 2012-03, Vol.31 (3), p.227-231
Hauptverfasser: Caporossi, Aldo, Mazzotta, Cosimo, Baiocchi, Stefano, Caporossi, Tomaso, Denaro, Rosario, Balestrazzi, Angelo
Format: Artikel
Sprache:eng
Schlagworte:
Aberrometry
Adolescent
Child
Collagen - drug effects
Cornea - drug effects
Cornea - radiation effects
Corneal Topography
Female
Follow-Up Studies
Humans
Italy
Keratoconus - drug therapy
Keratoconus - physiopathology
Male
Photochemotherapy
Photosensitizing Agents - therapeutic use
Prospective Studies
Riboflavin - therapeutic use
Ultraviolet Rays
Visual Acuity
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Zusammenfassung:PURPOSE:Evaluation of stability and functional response after riboflavin-UVA–induced cross-linking in a population of patients younger than 18 years with progressive keratoconus after 36 months of follow-up. METHODS:Prospective nonrandomized phase II open trial conducted at the Department of Ophthalmology, Siena University, Italy. The “Siena CXL Pediatrics” trial involved 152 patients aged 18 years or younger (10–18 years) with clinical and instrumental evidence of keratoconus progression. The population was divided into 2 groups according to corneal thickness (>450 and 450 μm) and +0.14 and +0.15 Snellen lines, respectively, in the thinner group (corneal thickness
ISSN:0277-3740
1536-4798
DOI:10.1097/ICO.0b013e31822159f6