Interactions between intracellular free Ca2+ and cyclic AMP in neuroendocrine cells

Interactions between intracellular free Ca2+ and cyclic AMP in neuroendocrine cells

Abstract Calcium ions and cyclic adenosine monophosphate (cAMP) are virtually ubiquitous intracellular signaling molecules in mammalian cells. This paper will focus on the cross-talk between Ca2+ and cAMP mobilizing signaling pathways and summarize the underlying molecular mechanisms. Subsequently,...

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Veröffentlicht in:Cell calcium (Edinburgh) 2012-03, Vol.51 (3), p.260-266
1. Verfasser: Antoni, Ferenc A
Format: Artikel
Sprache:eng
Schlagworte:
Adenylyl cyclase
Adrenocorticotropic Hormone - metabolism
Advanced Basic Science
Animals
Calcium
Calcium - chemistry
Calcium - metabolism
Calcium Signaling
cAMP
Corticotrophs - physiology
Cyclic AMP - metabolism
Humans
Neuroendocrine control
Phosphodiesterase
Second Messenger Systems - physiology
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Zusammenfassung:Abstract Calcium ions and cyclic adenosine monophosphate (cAMP) are virtually ubiquitous intracellular signaling molecules in mammalian cells. This paper will focus on the cross-talk between Ca2+ and cAMP mobilizing signaling pathways and summarize the underlying molecular mechanisms. Subsequently, workings of adenohypophyseal corticotrope cells will be reviewed to highlight the physiological relevance of a Ca2+ cAMP interactions in neuroendocrinology.
ISSN:0143-4160
1532-1991
DOI:10.1016/j.ceca.2011.12.013