Diclofenac induced liver injuries

We report the case of an 83-year-old female patient who developed diclofenac-associated liver injury nine days after therapy had started. Diclofenac was used to treat back pain associated with an acute exacerbation of a chronic lumbovertebral symptoms reversed. We discuss the adverse reaction profil...

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Veröffentlicht in:	Praxis (Bern. 1994) 2012-03, Vol.101 (6), p.371-379
Hauptverfasser:	Nezic, L, Krähenbühl, S, Rätz Bravo, A E
Format:	Artikel
Sprache:	ger
Schlagworte:	Aged, 80 and over Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - epidemiology Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - prevention & control Cross-Sectional Studies Diagnosis, Differential Diclofenac - adverse effects Diclofenac - therapeutic use Drug Interactions Drug Therapy, Combination Female Humans Liver Function Tests Risk Factors Spondylosis - drug therapy Switzerland
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Beschreibung
Zusammenfassung:	We report the case of an 83-year-old female patient who developed diclofenac-associated liver injury nine days after therapy had started. Diclofenac was used to treat back pain associated with an acute exacerbation of a chronic lumbovertebral symptoms reversed. We discuss the adverse reaction profile of diclofenac, particularly diclofenac-induced liver injury. We also discuss the epidemiology, clinical presentation and mechanisms of NSAID-induced liver injury, as well as risk factors and preventive measures.
ISSN:	1661-8157
DOI:	10.1024/1661-8157/a000880