Prognostic value of hemoglobin decline over the GRACE score in patients hospitalized for an acute coronary syndrome

In this work, we analyzed the prognostic significance of changes in hemoglobin during intensive care unit (ICU) stay in patients with acute coronary syndromes (ACS). We prospectively enrolled 591 patients (62 ± 14 years old, 73% male, 48% ST elevated myocardial infarction) free of blood cell transfusion or bleeding events. Changes in hemoglobin between admission and ICU discharge were obtained. The primary endpoint was death or hospitalization for MI within 6 months. Hemoglobin decreased from 13.65 ± 1.77 to 13.17 ± 1.74 g/dl, p 77 year-old ( p = 0.0016), Killip class ≥2 ( p = 0.009), anemia ( p = 0.0064), decreased estimated glomerular filtration rate ( p = 0.003), and hemoglobin decline ≥0.9 g/dl ( p