Intranasally applied l -DOPA alleviates parkinsonian symptoms in rats with unilateral nigro-striatal 6-OHDA lesions

Highlights ► Acute effects of intranasally applied l -DOPA in hemiparkinsonian rats were examined. ► Intranasal l -DOPA administration reduced the forelimb slips on a horizontal grid. ► l -DOPA can bypass the blood-brain-barrier by the intranasal route.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain research bulletin 2012-02, Vol.87 (2), p.340-345
Hauptverfasser:	Chao, Owen Y, Mattern, Claudia, De Souza Silva, Angelica M, Weßler, Janet, Ruocco, Lucia A, Nikolaus, Susanne, Huston, Joseph P, Pum, Martin E
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Dihydroxyphenylacetic Acid - metabolism 6-Hydroxydopamine Administration, Intranasal Amphetamine - pharmacology Analysis of Variance Animals Antiparkinson Agents - administration & dosage Benserazide Benserazide - pharmacology Chromatography, High Pressure Liquid Corpus Striatum - drug effects Corpus Striatum - physiology Disease Models, Animal Dopamine - metabolism Electrochemistry Exploratory Behavior - drug effects Footslips Forelimb - physiology Forelimb use Functional Laterality - drug effects Functional Laterality - physiology Homovanillic Acid - metabolism Hydroxyindoleacetic Acid - metabolism Intranasal l-DOPA Levodopa - administration & dosage Male Motor Activity - drug effects Motor Skills - drug effects Neurology Oxidopamine - adverse effects Parkinsonian Disorders - chemically induced Parkinsonian Disorders - drug therapy Rats Rats, Wistar Substantia Nigra - drug effects Substantia Nigra - physiology Sympatholytics - adverse effects Turning behavior
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Beschreibung
Zusammenfassung:	Highlights ► Acute effects of intranasally applied l -DOPA in hemiparkinsonian rats were examined. ► Intranasal l -DOPA administration reduced the forelimb slips on a horizontal grid. ► l -DOPA can bypass the blood-brain-barrier by the intranasal route.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2011.11.004