In vitro efficacy of fosfomycin-containing regimens against methicillin-resistant Staphylococcus aureus in biofilms

Objectives To compare the in vitro antibacterial efficacy of antistaphylococcal antibiotics in combination with fosfomycin or rifampicin, using a biofilm model. Methods The antibacterial activities of fusidic acid, linezolid, vancomycin, teicoplanin, rifampicin, minocycline, fosfomycin and tigecycli...

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Veröffentlicht in:Journal of antimicrobial chemotherapy 2012-04, Vol.67 (4), p.944-950
Hauptverfasser: Tang, Hung-Jen, Chen, Chi-Chung, Cheng, Kuo-Chen, Toh, Han-Siong, Su, Bo-An, Chiang, Shyh-Ren, Ko, Wen-Chien, Chuang, Yin-Ching
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Sprache:eng
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Zusammenfassung:Objectives To compare the in vitro antibacterial efficacy of antistaphylococcal antibiotics in combination with fosfomycin or rifampicin, using a biofilm model. Methods The antibacterial activities of fusidic acid, linezolid, vancomycin, teicoplanin, rifampicin, minocycline, fosfomycin and tigecycline, individually and in fosfomycin or rifampicin combinations, were measured against planktonic or biofilm-embedded methicillin-resistant Staphylococcus aureus (MRSA) with susceptible and resistant breakpoint concentrations (SBCs and RBCs, respectively), using the MTT-staining method and by counting the number of cfu in the biofilms. Results Linezolid alone at its SBC, and fosfomycin, linezolid, minocycline and tigecycline at their RBCs, exhibited killing effects on biofilm-embedded MRSA (P 
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkr535