Antigen-binding site anatomy and somatic mutations in antibodies that recognize different types of antigens

Antigen-binding site anatomy and somatic mutations in antibodies that recognize different types of antigens

The number of antibody structures co‐crystallized with their respective antigens has increased rapidly in the last few years, thus offering a formidable source of information to gain insight into the structure–function relationships of this family of proteins. We have analyzed here 140 unique middle...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of molecular recognition 2012-03, Vol.25 (3), p.103-113
Hauptverfasser: Raghunathan, Gopalan, Smart, Jason, Williams, Joseph, Almagro, Juan Carlos
Format: Artikel
Sprache:eng
Schlagworte:
Algorithms
Amino Acid Motifs
Animals
Antibodies - chemistry
Antibodies - genetics
Antibody Affinity
Antigens - chemistry
Binding Sites, Antibody
Complementary-determining regions
Crystallography, X-Ray
Humans
Hydrogen Bonding
Hypervariable loops
Immunoglobulin Variable Region - chemistry
Immunoglobulins
Mice
Models, Molecular
Mutation
Protein Binding
Protein Engineering
Protein Structure, Tertiary
Somatic mutation
Specificity-determining residues
Surface Properties
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The number of antibody structures co‐crystallized with their respective antigens has increased rapidly in the last few years, thus offering a formidable source of information to gain insight into the structure–function relationships of this family of proteins. We have analyzed here 140 unique middle‐resolution to high‐resolution (
ISSN:0952-3499
1099-1352
DOI:10.1002/jmr.2158