Pannexin 1 forms an anion-selective channel

Pannexin 1 forms an anion-selective channel

Pannexin 1 (Panx1) is expressed in various mammalian tissues including the brain and immune cells. Here, we present evidence that Panx1 when expressed in mammalian cells, forms anion-selective channels, with a rank order of permeabilities: NO 3 −  > I −  > Br −  > Cl −  > F −  ≫ aspartat...

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Veröffentlicht in:Pflügers Archiv 2012-04, Vol.463 (4), p.585-592
Hauptverfasser: Ma, Weihong, Compan, Vincent, Zheng, Wenxuan, Martin, Elizabeth, North, R. Alan, Verkhratsky, Alexei, Surprenant, Annmarie
Format: Artikel
Sprache:eng
Schlagworte:
Anions - metabolism
Aspartic Acid - metabolism
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Line
Cell Membrane Permeability - physiology
Chlorides - metabolism
Connexins - metabolism
Glutamic Acid - metabolism
HEK293 Cells
Human Physiology
Humans
Ion Channels
Ion Channels - metabolism
Molecular Medicine
Nerve Tissue Proteins - metabolism
Neurosciences
Receptors
Receptors and Transporters
Voltage-Dependent Anion Channels - metabolism
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Zusammenfassung:Pannexin 1 (Panx1) is expressed in various mammalian tissues including the brain and immune cells. Here, we present evidence that Panx1 when expressed in mammalian cells, forms anion-selective channels, with a rank order of permeabilities: NO 3 −  > I −  > Br −  > Cl −  > F −  ≫ aspartate −  ≈ glutamate −  ≈ gluconate − . Single-channel Panx1-mediated currents have a unitary conductance around 68 pS. Our results show that Panx1 assembles into a membrane anion channel with a relatively low single-channel conductance.
ISSN:0031-6768
1432-2013
DOI:10.1007/s00424-012-1077-z