Syntheses of structurally-simplified and fluorescently-labeled neovibsanin derivatives and analysis of their neurite outgrowth activity in PC12 cells

The syntheses of several neovibsanin derivatives were carried out in order to elucidate the simple structure required for displaying neurite outgrowth activity. In addition, a fluorescent probe molecule was synthesized and the analysis of its behavior in the PC12 cell line showed that the neovibsani...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-03, Vol.22 (5), p.2089-2093
Hauptverfasser:	Imagawa, Hiroshi, Saijo, Hayato, Yamaguchi, Hitomi, Maekawa, Ken, Kurisaki, Takahiro, Yamamoto, Hirofumi, Nishizawa, Mugio, Oda, Masataka, Kabura, Michiko, Nagahama, Masahiro, Sakurai, Jun, Kubo, Miwa, Nakai, Megumi, Makino, Kosho, Ogata, Mitsuko, Takahashi, Hironobu, Fukuyama, Yoshiyasu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axonogenesis Biological and medical sciences cell growth chemical derivatives Diterpenes - analysis Diterpenes - chemical synthesis Diterpenes - chemistry Diterpenes - pharmacology diterpenoids fluorescence Fluorescent Dyes - chemistry Fluorescent indicators Fluorescent probe molecule Medical sciences Models, Molecular Neovibsanin derivative Neurite outgrowth activity neurites Neurites - drug effects Neurites - ultrastructure Neurogenesis - drug effects Neurons - cytology Neurons - drug effects Neurons - ultrastructure PC12 Cells Pharmacology. Drug treatments Pheochromocytoma cells Rats structure-activity relationships Structure–activity correlation synthesis Viburnum - chemistry
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Zusammenfassung:	The syntheses of several neovibsanin derivatives were carried out in order to elucidate the simple structure required for displaying neurite outgrowth activity. In addition, a fluorescent probe molecule was synthesized and the analysis of its behavior in the PC12 cell line showed that the neovibsanins accumulate on the outer edge of the cell at the site of formation of prominences.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2012.01.006