Structure–activity relationship of the 7-hydroxy benzimidazole analogs as glycogen synthase kinase 3β inhibitor

Design, synthesis and the GSK3β inhibitory activities of the 7-hydroxy benzimidazole analogs are described. The solid-phase synthetic route was also developed for preparation of the analogs consisting of the novel ATP competitive scaffold. In addition, the structure–activity relationship of the 7-hy...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-03, Vol.22 (5), p.1891-1894
Hauptverfasser:	Lee, Seung-Chul, Shin, Dongkyu, Cho, Joong Myung, Ro, Sunggu, Suh, Young-Ger
Format:	Artikel
Sprache:	eng
Schlagworte:	7-Hydroxy benzimidazole adenosine triphosphate benzimidazole Benzimidazoles - chemistry Benzimidazoles - pharmacology Binding Sites Biological and medical sciences Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 - chemistry Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta glycogen synthase kinases GSK3 inhibitor Humans Medical sciences Models, Molecular Pharmacology. Drug treatments Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Structure-Activity Relationship structure-activity relationships
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Beschreibung
Zusammenfassung:	Design, synthesis and the GSK3β inhibitory activities of the 7-hydroxy benzimidazole analogs are described. The solid-phase synthetic route was also developed for preparation of the analogs consisting of the novel ATP competitive scaffold. In addition, the structure–activity relationship of the 7-hydroxy benzimidazole analogs and their biological activities are reported.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2012.01.065