Comparison of Recipient Outcomes Following Transplant From Local Versus Imported Pancreas Donors

The shortage of deceased donor organs for solid organ transplantation continues to be an ongoing dilemma. One approach to increase the number of pancreas transplants is to share organs between procurement regions. To assess for the effects of organ importation, we reviewed the outcomes of 1014 patie...

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Veröffentlicht in:American journal of transplantation 2012-02, Vol.12 (2), p.447-457
Hauptverfasser: Finger, E. B., Radosevich, D. M., Bland, B. J., Dunn, T. B., Chinnakotla, S., Sutherland, D. E. R., Pruett, T. L., Kandaswamy, R.
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Sprache:eng
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Zusammenfassung:The shortage of deceased donor organs for solid organ transplantation continues to be an ongoing dilemma. One approach to increase the number of pancreas transplants is to share organs between procurement regions. To assess for the effects of organ importation, we reviewed the outcomes of 1014 patients undergoing deceased donor pancreas transplant at a single center. We performed univariate and multivariate analyses of the association of donor, recipient and surgical characteristics with patient outcomes. Organ importation had no effect on graft or recipient survival for recipients of solitary pancreas transplants. Similarly, there was no effect on technical failure rate, graft survival or long‐term patient survival for simultaneous kidney–pancreas (SPK) recipients. In contrast, there was a significant and independent increased risk of death in the first year in SPK recipients of imported organs. SPK recipients had longer hospitalizations and increased hospital costs. This increased medical complexity may make these patients more susceptible to short‐term complications resulting from the longer preservation times of import transplants. These findings support the continued use of organ sharing to reduce transplant wait times but highlight the importance of strategies to reduce organ preservation times. Comparison of outcomes in pancreas transplant recipients of locally recovered versus imported organs demonstrates no differences in patient or graft survival except for simultaneous kidney‐pancreas recipients where there is a reduced first‐year patient survival that may be due to complications arising from longer preservation times.
ISSN:1600-6135
1600-6143
DOI:10.1111/j.1600-6143.2011.03828.x