Serum from interferon- beta -1b-treated patients with early multiple sclerosis stabilizes the blood-brain barrier in vitro

Serum from interferon- beta -1b-treated patients with early multiple sclerosis stabilizes the blood-brain barrier in vitro

Interferon- beta (IFN- beta ) stabilizes the blood-brain barrier (BBB) in vitro. Here we investigated the effect of serum from 15 IFN- beta -1b-treated multiple sclerosis (MS) patients on the permeability read-outs of small solutes in an in vitro BBB model consisting of human brain microvascular end...

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Veröffentlicht in:Multiple sclerosis 2012-02, Vol.18 (2), p.236-239
Hauptverfasser: Mueller, Marcus, Frese, Achim, Nassenstein, Isabelle, Hoppen, Maike, Marziniak, Martin, Ringelstein, Erich Bernd, Kim, Kwang Sik, Schaebitz, Wolf-Ruediger, Kraus, Jorg
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Sprache:eng
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Zusammenfassung:Interferon- beta (IFN- beta ) stabilizes the blood-brain barrier (BBB) in vitro. Here we investigated the effect of serum from 15 IFN- beta -1b-treated multiple sclerosis (MS) patients on the permeability read-outs of small solutes in an in vitro BBB model consisting of human brain microvascular endothelial cells in co-culture with rat astrocytes. The addition of sera from IFN- beta -treated patients resulted in a significantly (p
ISSN:1352-4585
DOI:10.1177/1352458511416837