Antibodies to Acetylcholine Receptors in Assessment of the Efficacy of Pathogenetic Treatment Patients with Myasthenia

Antibodies to Acetylcholine Receptors in Assessment of the Efficacy of Pathogenetic Treatment Patients with Myasthenia

Antibodies to acetylcholine receptors (AChR) were studied in 25 patients with myasthenia before and during treatment with glucocorticoids and in 22 patients before and after thymectomy. In 62% of patients, treatment effects were combined with decreases in anti-AChR antibody concentrations by 20% or...

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Veröffentlicht in:Neuroscience and behavioral physiology 2011-10, Vol.41 (9), p.889-893
Hauptverfasser: Sidnev, D. V., Sanadze, A. G., Dedaev, S. I., Karganov, M. Yu, Alchinova, I. B.
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholine receptors
Antibodies
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Glucocorticoids
Immunology
Myasthenia
Nervous system
Neurobiology
Neuromuscular junctions
Neurosciences
Thymectomy
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Zusammenfassung:Antibodies to acetylcholine receptors (AChR) were studied in 25 patients with myasthenia before and during treatment with glucocorticoids and in 22 patients before and after thymectomy. In 62% of patients, treatment effects were combined with decreases in anti-AChR antibody concentrations by 20% or more. In 15% of cases, despite improvement in patients’ clinical status, anti-AChR antibody levels showed no change or increased. A direct correlation was found between the extent of clinical improvement and the extent of reductions in anti-AChR antibody concentrations.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-011-9504-8