Metabolic Flux Analysis and Principal Nodes Identification for Daptomycin Production Improvement by Streptomyces roseosporus

In the present work, a comprehensive metabolic network of Streptomyces roseosporus LC-54-20 was proposed for daptomycin production. The analysis of extracellular metabolites throughout the batch fermentation was evaluated in addition to daptomycin and biomass production. Metabolic flux distributions...

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Veröffentlicht in:	Applied biochemistry and biotechnology 2011-12, Vol.165 (7-8), p.1725-1739
Hauptverfasser:	Huang, Di, Jia, Xiaoqiang, Wen, Jianping, Wang, Guoying, Yu, Guanghai, Caiyin, Qinggele, Chen, Yunlin
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Bacteria Biochemistry Biological and medical sciences Biosynthesis Biotechnology Chemistry Chemistry and Materials Science Daptomycin - biosynthesis Fermentation Fluctuations Fundamental and applied biological sciences. Psychology Glucose-6-Phosphate - metabolism Glyceric Acids - metabolism Kinetics Metabolism Metabolites Methods. Procedures. Technologies Microbial engineering. Fermentation and microbial culture technology Phosphoenolpyruvate - metabolism Streptomyces Streptomyces - metabolism
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