CD205 antigen targeting combined with dendritic cell recruitment factors and antigen-linked CD40L activation primes and expands significant antigen-specific antibody and CD4+ T cell responses following DNA vaccination of outbred animals
Highlights ► We tested immunogenicity of a CD205-targeted antigen fused to CD40L. ► We tested effectiveness of a single low dose. ► Immunization of MHC class II-matched calves induced significant immune responses. ► Primed immune responses were significantly expanded three weeks post-immunization. ►...
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Veröffentlicht in: | Vaccine 2012-02, Vol.30 (9), p.1624-1635 |
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