Tissue-specific distribution of aberrant DNA methylation associated with maternal low-folate status in human neural tube defects

This study compares the density and tissue-specific distribution of 5-methyl cytosine (5mC) in genomic DNA from human fetuses with or without neural tube defects (NTD) and examines whether low maternal serum folate is a possible correlate and/or risk factor for NTD. The results demonstrate significa...

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Veröffentlicht in:	The Journal of nutritional biochemistry 2011-12, Vol.22 (12), p.1172-1177
Hauptverfasser:	Chang, Huibo, Zhang, Ting, Zhang, Zhiping, Bao, Rui, Fu, Chengbo, Wang, Zhigang, Bao, Yihua, Li, Yuanyuan, Wu, Lihua, Zheng, Xiaoying, Wu, Jianxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Brain Cytosine Developmental stages DNA DNA Methylation Feeding. Feeding behavior Female Fetus Fetuses Folate deficiency Folic acid Folic Acid - blood Folic Acid Deficiency - genetics Folic Acid Deficiency - metabolism Fundamental and applied biological sciences. Psychology Genome, Human genomics Heart Human fetus Humans Hypomethylation Kidney kidneys Liver Neural Tube - pathology Neural tube defect Neural tube defects Neural Tube Defects - genetics Organ Specificity pathogenesis Pregnancy Pregnancy Complications - genetics Pregnancy Complications - metabolism Risk Factors Skin Tissue-specific methylation Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Beschreibung
Zusammenfassung:	This study compares the density and tissue-specific distribution of 5-methyl cytosine (5mC) in genomic DNA from human fetuses with or without neural tube defects (NTD) and examines whether low maternal serum folate is a possible correlate and/or risk factor for NTD. The results demonstrate significant hypomethylation of brain genomic DNA in NTD fetuses relative to controls (P
ISSN:	0955-2863 1873-4847
DOI:	10.1016/j.jnutbio.2010.10.003