A fluorinated analog of ISO-1 blocks the recognition and biological function of MIF and is orally efficacious in a murine model of colitis

A promising therapeutic approach to diminish pathological inflammation is to inhibit the synthesis and/or biological activity of macrophage migration inhibitory factor (MIF). Prior studies have shown that intraperitoneal administration of small-molecule inhibitors targeting the catalytic pocket of M...

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Veröffentlicht in:	European journal of pharmacology 2009-04, Vol.607 (1), p.201-212
Hauptverfasser:	Dagia, Nilesh M., Kamath, Divya V., Bhatt, Pooja, Gupte, Ravindra D., Dadarkar, Shruta S., Fonseca, Lyle, Agarwal, Gautam, Chetrapal-Kunwar, Anshu, Balachandran, Sarala, Srinivasan, Shaila, Bose, Julie, Pari, Koteppa, B-Rao, Chandrika, Parkale, Santosh S., Gadekar, Pradip K., Rodge, Atish H., Mandrekar, Noopur, Vishwakarma, Ram A., Sharma, Somesh
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Biological and medical sciences Cell Line Colitis - drug therapy Colitis - physiopathology Colon Cytokine Dextran Sulfate Disease Models, Animal Dopachrome Drug Delivery Systems Humans Inflammation Intramolecular Oxidoreductases - antagonists & inhibitors ISO-1 Isoxazoles - administration & dosage Isoxazoles - chemistry Isoxazoles - pharmacology Macrophage Migration-Inhibitory Factors - antagonists & inhibitors Macrophage Migration-Inhibitory Factors - biosynthesis Medical sciences Mice Mice, Inbred C57BL MIF Monocytes - drug effects Monocytes - metabolism Pharmacology. Drug treatments Quinolines - administration & dosage Quinolines - chemistry Quinolines - pharmacology
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