Influenza Virus Resistance to Neuraminidase Inhibitors: Implications for Treatment

Influenza Virus Resistance to Neuraminidase Inhibitors: Implications for Treatment

Oseltamivir and Zanamivir are the two main Neuraminidase inhibitors used for the treatment of Influenza. Oseltamivir resistance has been identified in non-pandemic influenza viruses, as well as H1N1 pandemic Influenza A viruses. Resistance is associated with increased morbidity, and poorer outcomes...

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Veröffentlicht in:Current infectious disease reports 2012-04, Vol.14 (2), p.155-160
Hauptverfasser: Shankaran, Shivanjali, Bearman, Gonzalo M. L.
Format: Artikel
Sprache:eng
Schlagworte:
Head
Infectious Diseases
Influenza
Inhibitors
Medicine
Medicine & Public Health
Neck Infections ( I. Brook
Pandemics
Resistance to control
Section Editor
Upper Respiratory
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Zusammenfassung:Oseltamivir and Zanamivir are the two main Neuraminidase inhibitors used for the treatment of Influenza. Oseltamivir resistance has been identified in non-pandemic influenza viruses, as well as H1N1 pandemic Influenza A viruses. Resistance is associated with increased morbidity, and poorer outcomes in severely immunocompromised hosts. Newer neuraminidase inhibitors, increased vaccination and combination therapy may be alternatives for the treatment of Influenza in this setting.
ISSN:1523-3847
1534-3146
DOI:10.1007/s11908-012-0236-x