Liquid chromatography–mass spectrometry method for the quantification of tamoxifen and its metabolite 4-hydroxytamoxifen in rat plasma: Application to interaction study with biochanin A (an isoflavone)

Tamoxifen is the agent of choice for the treatment of estrogen receptor-positive breast cancer. Tamoxifen is a substrate of P-glycoprotein (P-gp) and microsomal cytochrome P450 (CYP) 3A, and biochanin A (BCA) is an inhibitor of P-gp and CYP3A. Hence, it could be expected that BCA would affect the ph...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2011-10, Vol.879 (27), p.2845-2851
Hauptverfasser:	Singh, Sheelendra Pratap, Wahajuddin, Ali, Mushir M., Kohli, Kanchan, Jain, Girish Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Hydroxytamoxifen Analysis Analytical, structural and metabolic biochemistry Animals Area Under Curve Assaying Biological and medical sciences Centchroman Chromatography Chromatography, Liquid - methods Drug Interactions Female Fundamental and applied biological sciences. Psychology General pharmacology Genistein - administration & dosage Genistein - pharmacology Inhibitors Isoflavones LC–MS/MS Linearity Medical sciences Metabolites Pharmacokinetics Pharmacology. Drug treatments Rat plasma Rats Rats, Sprague-Dawley Regression Analysis Reproducibility of Results Sensitivity and Specificity Tamoxifen Tamoxifen - analogs & derivatives Tamoxifen - blood Tamoxifen - pharmacokinetics Tamoxifen - pharmacology Tandem Mass Spectrometry - methods Validation
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