Spindle cell oncocytoma of the adenohypophysis: Report of a rare case and review of literature

The tumor cells were strongly and diffusely immunopositive for vimentin (Novocastra, dil 1:100), S-100 (Dako Denmark, dil 1:1000) and showed granular cytoplasmic reactivity for epithelial membrane antigen (EMA) (Dako Denmark, dil 1:100), but were immunonegative for cytokeratin (Dako Denmark, dil 1:100), chromogranin (NeoMarker, dil 1:100), synaptophysin (NeoMarker, dil 1:100), smooth muscle actin (Dako Denmark, dil 1:100), growth hormone (NeoMarker, dil 1:500), prolactin (NeoMarker, 1:100), adrenocorticotropic hormone (NeoMarker, 1:100), leutinizing hormone (NeoMarker, dil 1:500), follicular stimulating hormone (NeoMarker, dil 1:500), thyroid stimulating hormone (NeoMarker, dil 1:100), glial fibrillary acidic protein (GFAP) (Dako, Denmark, 1:1000), bcl-2 (NeoMarker, dil 1:50) and p53 (Santa-Cruz, USA dil 1:50). [2] even after receiving radiotherapy. [...]it still remains to be determined whether these tumors are radiosensitive or not.